2 edition of Epstein-Barr virus and cell survival found in the catalog.
Epstein-Barr virus and cell survival
Sheila Ann Henderson
Thesis (Ph.D) - University of Birmingham, Dept of Cancer Studies.
|Statement||by Sheila Ann Henderson.|
Abstract. Epstein-Barr virus (EBV), a human gamma-herpesvirus, was the first virus linked causally with a human tumour, following its identification in by Epstein, Barr and Achong in a common childhood cancer in equatorial Africa named after Burkitt (Burkitt’s lymphoma or BL), who first described the by: 2. Endemic nasopharyngeal carcinoma (NPC) is associated with Epstein–Barr virus (EBV) type II latent infection, and tumor cells expressing such viral antigens are attractive targets for treatment. As tumor cell survival is dependent on their ability to evade T-cell immunity, immunotherapy in NPC traditionally focuses on restoration of T-cell.
Epstein–Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult population. Primary EBV infection usually occurs during childhood and is generally asymptomatic, though the virus can cause infectious mononucleosis in 35–50% of the cases when infection occurs later in life. EBV infects mainly B-cells and epithelial cells, establishing latency in resting memory B Cited by: 6. In the century preceding the discovery of Epstein-Barr virus (EBV), physicians speculated that a common clinical syndrome characterized by fever, tonsillar adenopathy, splenomegaly, and mononuclear leukocytosis termed glandular fever was caused by a pathogen (1). In , the name infectious mononucleosis (IM) was introduced by Thomas P. Sprunt and Frank A. Evans Cited by: 1.
Epstein-Barr virus (EBV) not only induces growth transformation in human B lymphocytes, but has more recently been shown to enhance B cell survival under suboptimal conditions where growth is inhibited; both effects are mediated through the coordinate action of . The metabolic landscape of Epstein–Barr-virus-associated gastric cancer (EBVaGC) remains to be elucidated. In this study, we used transcriptomics, metabolomics, and lipidomics to comprehensively investigate aberrant metabolism in EBVaGC. Specifically, we conducted gene expression analyses using microarray-based data from gastric adenocarcinoma epithelial cell Cited by: 1.
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Cancer Virus: The story of Epstein-Barr Virus - Kindle edition by Crawford, Dorothy H., Johannessen, Ingólfur, Rickinson, Alan B.
Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Cancer Virus: The story of Epstein-Barr Epstein-Barr virus and cell survival book.
Is Epstein-Barr Virus really Treatable and Reversible. It’s a such a polarizing question, and so much avoided, actually, due to common misconceptions about I can’t wait to say it once and for all, both to the clinicians and to those suffering from EBV and to the doctors and other practitioners, many of whom I have met, who themselves struggle with EBV: EBV may actually.
The Epstein-Barr virus (EBV) was discovered in At the time, the very idea of a virus underlying a cancer was revolutionary. Cancer is, after all, not catching. Even now, the idea of a virus causing cancer surprises many people.
But Epstein-Barr, named after its discoverers, Sir Anthony Epstein and Dr Yvonne Barr, is fascinating for other Cited by: 1. In vitro production of stable Epstein–Barr virus-positive epithelial cell clones which resemble the virus: cell interaction observed in nasopharyngeal carcinoma. VirologyCited by: Epstein-Barr virus was first reported by British scientists M.A.
Epstein, Y.M. Barr, and B.G. Achong, who found viruslike particles in cells grown from tissues involved with a newly described lymphatic Epstein-Barr virus is known to be able to infect only two different types of cells in the body: some salivary gland cells and one special type of white blood cell ().
Epstein–Barr Virus. Epstein–Barr virus (EBV) is a gamma-herpesvirus with a kb DNA genome, which infects more than 90% of world population. EBV is a successful virus that utilizes normal B cell biology to infect, persist, and replicate in B cells (Thorley-Lawson, ; Thorley-Lawson and Gross, ).Cited by: The Epstein Barr virus affects more individuals per year than you may know.
If you catch it, it will make you very sick. We'll explore here what Epstein Barr is, what it does, and what it looks like. Epstein-Barr virus (EBV) is a human gamma herpes virus that remains one of the most successful viral parasites known to man.
It is the etiological agent of infectious mononucleosis and is the major biological cofactor contributing to a number of human cancers including B-cell neoplasms (e.g. Burkitt's lymphoma, Hodgkin's disease and immunoblastic lymphomas), certain forms of.
1. Introduction. Epstein-Barr virus (EBV) has been suspected of involvement in the pathogenesis of various chronic autoimmune diseases since the finding of elevated levels of antibody to the virus in systemic lupus erythematosus (SLE) in .Generally the effect of EBV infection has been attributed to immunological cross-reactivity between EBV and self-antigens Cited by: The Epstein-Barr Virus M.O.
Unlike bacteria, which multiply comfortably on their own given the right environment, viruses need to insert themselves into a host's cells in order to persevere. Once a virus has taken a human cell hostage, it continues to conquer cell after cell. Epstein - Barr virus (EBV) is a gamma - herpes virus that infects more 90% of humans.
Most EBV primary infections and reactivations are subclinical and require no therapy in immunocompetent people. However, EBV infection or reactivation may result in life-threatening diseases in immunocompromised people [ 1 – 5 ].Cited by: 5.
The Epstein-Barr virus (EBV) was discovered in At the time, the very idea of a virus underlying a cancer was revolutionary. Cancer is, after all, not catching. Even now, the idea of a virus causing cancer surprises many people. But Epstein-Barr, named after its discoverers, Sir Anthony Epstein and Dr Yvonne Barr, is fascinating for other reasons too.
Epstein-Barr virus (EBV) infects over 90% of the world's population, and like other herpesviruses it establishes a permanent latent infection in the host (Rickinson and Kieff, ).
The native B-lymphocyte is the preferred target of EBV, which after differentiation into memory B-cells contains the latent reservoir of virus subsequent to the. Epstein-Barr virus (EBV) was discovered 40 years ago from examining electron micrographs of cells cultured from Burkitt's lymphoma, a childhood.
The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell. ; Medline, Google Scholar: 6.
Lo YM, Chan LY, Lo KW, et al. Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res. ; Medline, Google Cited by: Epstein-Barr virus (EBV), also called human herpesvirus 4 (HHV-4)- lymphoma The last of these, the Epstein-Barr virus (EBV), has always been a bit mysterious.
It is responsible for mononucleosis, and suspected of being a cause of chronic fatigue syndrome (CFS), although this disease remains poorly understood. b Epstein–Barr virus. Epstein–Barr virus (EBV) is a ubiquitous herpes virus that infects most children during early childhood and causes few, if any, symptoms.
However, EBV is involved in several types of lymphomas and a subset (about 9%) of gastric carcinomas, although its specific role in gastric carcinogenesis remains unclear.
Epstein-Barr virus (EBV) was the first recognized human tumor virus, but it is not the causative agent for the tumor in which it was discovered, Burkitt lymphoma.
Common to all Burkitt lymphomas, endemic or sporadic, are distinctive chromosomal translocations that reactivate expression of the c-myc protooncogene and comprise the primary.
Epstein–Barr virus (EBV), also known as human herpesvirus 4 (HHV-4), is one of the eight known lymphotropic herpesviruses . EBV most commonly causes infectious mononucleosis, also known as glandular fever, which is characterised by fever, sore throat, and lymphadenopathy .
Zuo J, Thomas WA, Haigh TA, Fitzsimmons L, Long HM, Hislop AD, Taylor GS, Rowe M () Epstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl PLoS Pathog 7:e PubMedCentral PubMed CrossRef Google ScholarCited by:.
Special white blood cells called Epstein Barr virus specific T-cells (T cells that have been trained to kill cells infected by EBV) can survive in the blood and affect the tumor.
Giving nivolumab and Epstein Barr virus specific T-cells may work better in treating participants with relapsed or refractory EBV-positive lymphoma. Epstein-Barr virus (EBV) not only induces growth transformation in human B lymphocytes, but has more recently been shown to enhance B cell survival under suboptimal conditions where growth is.
Epstein-Barr virus (EBV) is an opportunistic human pathogen that causes a significant number of diseases in immunocompromised hosts. EBV is etiologically linked with the development of numerous B lymphocyte and epithelial cell malignancies, including Burkitt, Hodgkin, AIDS-associated, and posttransplant lymphomas and nasopharyngeal carcinoma Cited by: